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Glucosamine zeigt positiven Effekt bei der Behandlung oder Vermeidung von Knorpelverlust.

Effect of glucosamine on interleukin-1-conditioned articular cartilage

https://pubmed.ncbi.nlm.nih.gov/12405690/ (PDF)

Glucosamine fördert die Erholung der Gelenkmobilität und scheint den Knorpellabbau zu verlangsamen.

A review of articular cartilage pathology and the use of glucosamine sulfate

https://pubmed.ncbi.nlm.nih.gov/16558667/ (PDF)

Einnahme von Glucosamine hilft den Krankheitsverlauf von Athrose zu stabilisieren.

Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study

https://pubmed.ncbi.nlm.nih.gov/12374520/ (PDF)

Einsatz von Glucosamine/Chondroitin führt zur Schmerzreduzierung bei Hunden mit Arthrose.

Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis

"Thirty-five dogs were included in a randomised, double-blind, positive controlled, multi-centre trial to assess the efficacy of an orally-administered glucosamine hydrochloride and chondroitin sulfate (Glu/CS) combination for the treatment of confirmed osteoarthritis of hips or elbows. [...] Response to treatment was based on subjective evaluation by participating veterinarians who recorded their findings at each visit. Dogs treated with Glu/CS showed statistically significant improvements in scores for pain, weight-bearing and severity of the condition by day 70. [...] The results show that Glu/CS has a positive clinical effect in dogs with osteoarthritis."

https://pubmed.ncbi.nlm.nih.gov/16647870/

Literatur: Chondroitin Sulfat beeinflusst den Stoffwechsel der Gelenkknorpel. Studien belegen Minderung der Gelenkschmerzen im Vergleich zu Kontrollgruppen.

Nutraceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondroitin sulfate, and collagen hydrolysate

https://pubmed.ncbi.nlm.nih.gov/10356424/ (PDF auf Anfrage)

Literatur: Chondroitinsulfat ist essenziell für die strukturelle und funktionale Unversehrtheit der Gelenke, da sie die Mehrheit der Glykosaminoglykane (GAGs) im Gelenkknorpel darstellt.

Glucosamine and chondroitin for osteoarthritis

https://pubmed.ncbi.nlm.nih.gov/19094424/ (PDF)

EULAR, die Europäische Allianz der Verbände für Rheumatologie, belegt in ihrem 2003 Bericht dass Chondroitin einen mittel bis grossen Effekt auf Schmerzen bei Athrose hat.

EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)

https://ard.bmj.com/content/62/12/1145.long (PDF)

Diese Studie zeigt beim längerfristigen Einsatz von Glucosamine/Chondroitin eine allgemeine Schmerzreduzierung von 51% (43% nach physikalischer Anstrengung) bei Hunden mit Athrose. Nebenwirkungen wurden keine festgestellt.

Comparative therapeutic efficacy and safety of type-II collagen (UC-II), glucosamine and chondroitin in arthritic dogs: pain evaluation by ground force plate

"Dogs receiving UC-II (Group-II) showed significant reduction in pain by day 60, but the maximum reduction in pain was observed on day 150 (overall pain, 81%; pain after limb manipulation, 87%; and pain after physical exertion, 90%). Group-III dogs receiving GLU + CHO exhibited significant reduction in pain by day 90 with maximal effects on day 150 (overall pain, 51%; pain after limb manipulation, 48%; and pain after physical exertion, 43%) [...] None of the dogs receiving dietary supplements showed any signs of adverse effects."

https://pubmed.ncbi.nlm.nih.gov/21623931/

Studie, die die Entzündungshemmung von Methylsulfonylmethan (MSM) belegt.

The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages

https://pubmed.ncbi.nlm.nih.gov/19336900/ (PDF)

Schmerzreduzierung bei Athrose beim Einsatz von Methylsulfonylmethan (MSM).

Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial

"Results: Compared to placebo, MSM produced significant decreases in WOMAC pain and physical function impairment. No notable changes were found in WOMAC stiffness and aggregated total symptoms scores. MSM also produced improvement in performing activities of daily living when compared to placebo on the SF-36 evaluation. Conclusion: MSM (3g twice a day) improved symptoms of pain and physical function during the short intervention without major adverse events."

https://pubmed.ncbi.nlm.nih.gov/16309928/

Studie, die die Entzündungshemmung und Schmerzreduzierung von Methylsulfonylmethan (MSM) bei Gelenkproblemen belegt.

Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis

"Glu, MSM and their combination significantly improved signs and symptoms of osteoarthritis compared with placebo. There was a statistically significant decrease in mean (+/- SD) pain index from 1.74 +/- 0.47 at baseline to 0.65 +/- 0.71 at week 12 with Glu (p < 0.001). MSM significantly decreased the mean pain index from 1.53 +/- 0.51 to 0.74 +/- 0.65, and combination treatment resulted in a more significant decrease in the mean pain index (1.7 +/- 0.47 to 0.36 +/- 0.33; p < 0.001). After 12 weeks, the mean swelling index significantly decreased with Glu and MSM, while the decrease in swelling index with combination therapy was greater (1.43 +/- 0.63 to 0.14 +/- 0.35; p < 0.05) after 12 weeks. The combination produced a statistically significant decrease in the Lequesne index. All treatments were well tolerated. [...] Glu, MSM and their combination produced an analgesic and anti-inflammatory effect in osteoarthritis. Combination therapy showed better efficacy in reducing pain and swelling and in improving the functional ability of joints than the individual agents. All the treatments were well tolerated. The onset of analgesic and anti-inflammatory activity was found to be more rapid with the combination than with Glu. It can be concluded that the combination of MSM with Glu provides better and more rapid improvement in patients with osteoarthritis."

https://pubmed.ncbi.nlm.nih.gov/17516722/

Studie, die die Schmerzreduzierung von Methylsulfonylmethan (MSM) in Kombination mit Glucosamine/Chondroitin bei Athrose belegt.

Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial

"Combination of glucosamine-chondroitin sulfate-MSM showed a significant clinical improvement especially in terms of pain relief in patients with grade I-II Kellgren Lawrence of knee osteoarthritis (OA) compared with glucosamine-chondroitin sulfate and placebo. Glucosamine-chondroitin sulfate may bring significant clinical improvement in patients with grade I-II Kellgren Lawrence of knee OA compared to placebo; however, the supplement could not significantly reduce pain."

https://pubmed.ncbi.nlm.nih.gov/28790224/ (PDF)

Studie, die die Wirksamkeit von Grünlippmuschel bei Hunden mit Gelenkproblemen belegt.

Clinical efficacy and tolerance of an extract of green-lipped mussel (Perna canaliculus) in dogs presumptively diagnosed with degenerative joint disease

https://pubmed.ncbi.nlm.nih.gov/16751841/ (PDF)

Studie die die Wirksamkeit von Grünlippmuschel bei Hunden mit Athrose belegt. Beim Einsatz von Grünlippmuschel wurden reduzierte Gelenkschmerzen und Schwellungen der Gelenke festgestellt. Die Studie liefert starke Beweise dass das Füttern von Grünlippmuschel bei Hunden mit Athrose die Leiden reduzieren kann.

Influence of green lipped mussels (Perna canaliculus) in alleviating signs of arthritis in dogs

"This study evaluated the efficacy of green lipped mussel (GLM), added to a complete dry diet, for alleviating clinical signs of arthritis in dogs. A double-blind longitudinal study design was used with 31 mixed-breed dogs exhibiting varying degrees of arthritis. Each dog was evaluated by a veterinarian and joints were individually scored for degree of pain, swelling, crepitus, and reduction in range of movement. Summation of all scores for an individual dog comprised its total arthritis score. At baseline, dogs were randomly allocated to control and test groups. Both groups were fed the same base dry diet, to which 0.3% GLM powder was added for dogs in the test group. The change in total arthritis score by the end of 6 weeks showed there was significant improvement (P <.05) in the test group versus the control group. Significant improvements were also observed in joint pain and swelling scores in the test group. Changes in joint crepitus and range of joint movement were not significantly different between the test and control groups. These findings provide strong evidence that GLM incorporated into a complete dry diet can help alleviate arthritis symptoms in dogs."

https://pubmed.ncbi.nlm.nih.gov/15136981/ (PDF auf Anfrage)

Studie, die reduzierte Schmerzen, verbesserte Gangfunktion, Beweglichkeit sowie kräftigere Gelenke beim längeren Einsatz von Grünlippmuschel bei Hunden mit klinischer Arthrose belegt.

Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis

https://pubmed.ncbi.nlm.nih.gov/23814358/ (PDF)

Klinische Studie die verbesserte Beweglichkeit und reduzierte Schmerzen beim Füttern von Grünlippmuschel bei Hunden mit Arthrose belegt.

Evaluating Complementary Therapies for Canine Osteoarthritis Part I: Green-lipped Mussel (Perna canaliculus)

https://pubmed.ncbi.nlm.nih.gov/18955269/ (PDF)

Studie belegt positiven Effekt auf die Knochenregeneration bei Hunden nach Einnahme von Vitamin D3

Association of vitamin D3 with alveolar bone regeneration in dogs

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459836/ (PDF)

Studien belegen die Wirksamkeit von Vitamin D3 bei der Knochenbildung -und heilung.

The Effect of Vitamin D and Its Metabolites on Fracture Repair in Chicks

https://pubmed.ncbi.nlm.nih.gov/6309464/

24R,25-dihydroxyvitamin D3: an essential vitamin D3 metabolite for both normal bone integrity and healing of tibial fracture in chicks

https://pubmed.ncbi.nlm.nih.gov/9275076/ (PDF)

Short-term treatment of rats with high dose 1,25-dihydroxyvitamin D3 stimulates bone formation and increases the number of osteoblast precursor cells in bone marrow

https://pubmed.ncbi.nlm.nih.gov/9348188/ (PDF)

Einnahme von Vitamin E zeigt eine Reduzierung der Gelenkmarker für Entzündungen sowie einen positiven Trend bei der Verbesserung der Gelenkschmerzen bei Hunden mit Athrose.

Anti-inflammatory response of dietary vitamin E and its effects on pain and joint structures during early stages of surgically induced osteoarthritis in dogs

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700444/ (PDF)

Penberthy WT, Sadri M, Zempleni J (2020). "Biotin". In BP Marriott, DF Birt, VA Stallings, AA Yates (eds.). Present Knowledge in Nutrition, Eleventh Edition. London, United Kingdom: Academic Press (Elsevier). pp. 289–304.

https://www.sciencedirect.com/topics/earth-and-planetary-sciences/biotin

Combination of chromium and biotin improves coronary risk factors in hypercholesterolemic type 2 diabetes mellitus: a placebo-controlled, double-blind randomized clinical trial

https://pubmed.ncbi.nlm.nih.gov/17684468/